A Promising Baldness Cure
Apart from surgical treatment for Baldness or Hair Loss, other commonly used treatments on Hair Loss are known to be effective only for long durations, often at small improvements over time.
Most often than not, such methods require few to several months of continued practice in order to show first result which makes our present methods of treatment an emotionally painful slow and long process; sometimes, even ineffective at the most severe cases.
For a person who is already experiencing a progressing case of Baldness, further loss of Hair can be distressing, if not be a cause of self-esteem issues for both Men and Women alike, especially for the latter whose occurrence of the condition is considered to be less than their male counterparts.
However, there is a more recent study that tries to break the notion about how non-surgical modern-day treatments about Hair Loss work in terms of the time it takes to produce significant effect towards users – Faster Hair Growth.
Promising Hair Growth on Experiments
The Columbia University Medical Center has been pretty busy of late with Angela Christiano at the helm of an experiment on Mice and Human Hair Follicles which shows the potential of a drug that promotes rapid Hair Growth when applied on the skin as a topical product which inhibits a family of enzymes known as the Janus Kinase (JAK).
The research showed a remarkable result: the mice that were treated with one of two JAK inhibitors showed initial Hair Growth on the subjects in as early as 10 days after days of trials which showed a great potential in greatly boosting hair growth at its onset.
In just three weeks with the experiment, the subjects have their Hair grown.
On the other hand, the controlled subjects did not show any significant changes with the experiment.
How the drug works is simple: by inhibiting Janus Kinase, a family on enzymes found within the Hair Follicles, the hair’s root go through a normal re-awakening process thereby making hairs grow.
Because of the research, the possibility of the use of JAK inhibitors as a treatment in Hair Loss, such as that caused by Male Pattern Baldness or other causes of Hair Loss as a result of Hair Follicles getting trapped in their resting state, has increased as was published recently in Science Advances’ online edition.
So far, two JAK inhibitors have already gone approval by the U.S. Food and Drug Administration (USFDA) but not necessarily as a treatment for Hair Loss – one, Ruxolitinib was approved for treatment of blood-related diseases while the other, Tofacitinib, was meant for Rheumatoid Arthritis.
Clinical Tests for Other Possible Baldness Cure
Apart from the mentioned, both JAK inhibitors are also undergoing clinical tests as a treatment against Hair Loss-Causing auto-immune diseases, Alopecia Areata and Plaque Psoriasis.
Originally intended to study Alopecia Areata, a cause of Hair Loss that results from our body’s own auto-immune attack on hair follicles, Christiano and colleagues came across the discovery of the influence of JAK inhibitors on hair follicles.
When given in a systematic manner, Dr. Christiano observed that the drug caused the mice, as subjects, to grow more hair as tested and applied on their skin which implied a positive reaction in the hair follicles apart from preventing the auto-immune attack in the subject’s body.
Knowing how hair follicles work, they do not grow at a steady phase but as a result of a cycle between active and dormant phases.
The researchers therefore found the positive correlation between the JAK inhibitors and the hair follicle’s natural re-awakening process.
According to Dr. Christiano, there are not that many compounds known in the medical science which promotes hair of its growth from its root so quickly as the discovered JAK inhibitors.
Displaying good affinity to the human hair as was seen with the experiment, hair follicles grown in culture such as those that were grafted onto the subjects produce longer hair in comparison to those natural to the subject.
With the likely similarities about how the drug acts on certain pathways between a human hair follicle and those endemic to the subjects, the result suggests the potential of the drug to stimulate hair growth and extend on the length of dormant hairs in humans.
Furthering the scope of the research, topics such as the relation of the hair follicles with Hair Loss Disorders are now afoot.